FAILURE OF CHLOROQUINE-ERYTHROMYCIN AND CHLOROQUINE-TETRACYCLINE COMBINATIONS IN TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN EASTERN THAILAND

• Main Authors: Rodney E. Phillips, Juntra Karbwang, Nicholas J. White, Sornchai Looareesuwan, David A. Warrell, Prakit Kasemsarn, David C. Warhurst
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/30665

In Eastern Thailand the increasing resistance of Plasmodium falciparum to all available antimalarial drugs prompted a reassessment of chloroquine in combination with either erythromycin or tetracycline. Both combinations had produced encouraging results in vitro, in experimental animal models, or in...