Molecular characterization of Plasmodium falciparum uracil-DNA glycosylase and its potential as a new anti-malarial drug target

• Main Authors: Thidarat Suksangpleng, Ubolsree Leartsakulpanich, Saengduen Moonsom, Saranya Siribal, Usa Boonyuen, Wright, George E, Porntip Chavalitshewinkoon-Petmitr
• Other Authors: Mahidol University. Faculty of Tropical Medicine. Department of Protozoology
• Format: Research Report
• Language: English
• Published: 2017
• Subjects: Open Access article; Plasmodium falciparum; Malaria; Uracil-DNA glycosylase; Antimalarials; Drug target
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/3069
• Institution: Mahidol University

Background: Based on resistance of currently used anti-malarials, a new anti-malarial drug target against Plasmodium falciparum is urgently needed. Damaged DNA cannot be transcribed without prior DNA repair; therefore, uracil-DNA glycosylase, playing an important role in base excision repair, may...