Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria

• Main Authors: Katherine Plewes, Royakkers, Annick A, Josh Hanson, Md Mahtab Uddin Hasan, Shamsul Alam, Aniruddha Ghose, Maude, Richard J, Stassen, Pauline M, Prakaykaew Charunwatthana, Lee, Sue J, Turner, Gareth DH, Dondorp, Arjen M, Schultz, Marcus J
• Other Authors: Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
• Format: Research Report
• Language: English
• Published: 2017
• Subjects: Open Access article; Acute kidney Injury; Pathophysiology; Falciparum malaria; Soluble urokinase-type plasminogen activator receptor; Histidine rich protein-2
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/3071
• Institution: Mahidol University

Background: Acute kidney injury (AKI) complicating severe Plasmodium falciparum malaria occurs in up to 40% of adult patients. The case fatality rate reaches 75% in the absence of renal replacement therapy (RRT). The precise pathophysiology of AKI in falciparum malaria remains unclear. Histopathol...