Studies of Zoapatle I. The Extraction of Zoapatle (Montanoa Tomentosa) and the Identification of 21 -normontanol as the Initial Decomposition Product of Zoapatanol

Studies of Zoapatle I. The Extraction of Zoapatle (Montanoa Tomentosa) and the Identification of 21 -normontanol as the Initial Decomposition Product of Zoapatanol

Hot H2O and hexane were found to be inappropriate to extract zoapatanol (1) from the leaves of Montanoa tomentosa ssp. tomentosa; EtOH and EtOAc, on the other hand, were far more effective. A number of Montanoa species and subspecies were examined for the presence of zoapatanol (1). Zoapatanol is hi...

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Bibliographic Details
Main Authors: Guido B. Marcelle, Nuntavan Bunyapraphatsara, Geoffrey A. Cordell, Harry H.S. Fong, Kyriakos C. Nicolaou, Robert E. Zipkin
Other Authors: University of Illinois at Chicago
Format: Article
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/30762
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Institution: Mahidol University
Description
Summary:Hot H2O and hexane were found to be inappropriate to extract zoapatanol (1) from the leaves of Montanoa tomentosa ssp. tomentosa; EtOH and EtOAc, on the other hand, were far more effective. A number of Montanoa species and subspecies were examined for the presence of zoapatanol (1). Zoapatanol is highly unstable either neat or in aqueous solution at elevated temperatures, and only samples dissolved in solvent and stored at — 5 to — 10° have extended half-lives. The initial decomposition product of zoapatanol (1) has been identified as 21-normontanol (2) through high field proton nmr analysis. © 1985, American Chemical Society. All rights reserved.

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