Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency

• Main Authors: Sim Kheng, Sinoun Muth, Taylor, Walter R. J., Narann Tops, Khem Kosal, Khon Sothea, Phum Souy, Saorin Kim, Char, Chuor Meng, Chan Vanna, Po Ly, Pascal Ringwald, Virak Khieu, Alexandra Kerleguer, Pety Tor, Baird, John K., Steven Bjorge, Didier Menard, Eva Christophel
• Other Authors: Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
• Format: Article
• Language: English
• Published: 2017
• Subjects: Open Access article; weekly primaquine; Plasmodium vivax; glucose-6-phosphate dehydrogenase deficiency
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/3092
• Institution: Mahidol University

Background: Primaquine is used to prevent Plasmodium vivax relapse; however, it is not implemented in many malaria-endemic countries, including Cambodia, for fear of precipitating primaquine-induced acute haemolytic anaemia in patients with glucose-6-phosphate dehydrogenase deficiency (G6PDd). Rel...