Use of a rapid test to assess plasma Plasmodium falciparum HRP2 and guide management of severe febrile illness

• Main Authors: Ipsita Sinha, Nattwut Ekapirat, Dondorp, Arjen M., Woodrow, Charles J.
• Other Authors: Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit (MORU)
• Format: Research Report
• Language: English
• Published: 2017
• Subjects: Open Access article; Falciparum malaria; Severe febrile illness; PfHRP2; Plasma; Rapid test
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/3097
• Institution: Mahidol University

Background: Plasma Plasmodium falciparum histidine-rich protein-2 (PfHRP2) is the most accurate biomarker for severe malaria, but its measurement by ELISA has been considered too unwieldy to incorporate into clinical management. Methods: Plasma samples covering a wide range of PfHRP2 concentratio...