Comparative genome‑wide analysis and evolutionary history of haemoglobin‑processing and haem detoxification enzymes in malarial parasites

• Main Authors: Patrath Ponsuwanna, Theerarat Kochakarn, Duangkamon Bunditvorapoom, Krittikorn Kümpornsin, Otto, Thomas D., Chase Ridenour, Kesinee Chotivanich, Prapon Wilairat, White, Nicholas J., Olivo Miotto, Thanat Chookajorn
• Other Authors: Mahidol University. Faculty of Tropical Medicine. Genomic and Evolutionary Medicine Unit, Centre of Excellence in Malaria
• Format: Article
• Language: English
• Published: 2017
• Subjects: Open Access article; malarial; parasites; haemoglobin
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/3105
• Institution: Mahidol University

Background: Malaria parasites have evolved a series of intricate mechanisms to survive and propagate within host red blood cells. Intra-erythrocytic parasitism requires these organisms to digest haemoglobin and detoxify ironbound haem. These tasks are executed by haemoglobin-specific proteases and...