High Number of Previous Plasmodium falciparum Clinical Episodes Increases Risk of Future Episodes in a Sub-Group of Individuals
There exists great disparity in the number of clinical P. falciparum episodes among children of the same age and living in similar conditions. The epidemiological determinants of such disparity are unclear. We used a data-mining approach to explore a nineteen-year longitudinal malaria cohort study d...
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th-mahidol.310692018-10-19T12:31:47Z High Number of Previous Plasmodium falciparum Clinical Episodes Increases Risk of Future Episodes in a Sub-Group of Individuals Cheikh Loucoubar Laura Grange Richard Paul Augustin Huret Adama Tall Olivier Telle Christian Roussilhon Joseph Faye Fatoumata Diene-Sarr Jean François Trape Odile Mercereau-Puijalon Anavaj Sakuntabhai Jean François Bureau Institut Pasteur, Paris CNRS Centre National de la Recherche Scientifique Institut Pasteur de Dakar Universite Paris Descartes Ecole des hautes etudes en sante publique Institute of Health and Science Institut de Recherche pour le Developpement Dakar Mahidol University Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Medicine There exists great disparity in the number of clinical P. falciparum episodes among children of the same age and living in similar conditions. The epidemiological determinants of such disparity are unclear. We used a data-mining approach to explore a nineteen-year longitudinal malaria cohort study dataset from Senegal and identify variables associated with increased risk of malaria episodes. These were then verified using classical statistics and replicated in a second cohort. In addition to age, we identified a novel high-risk group of children in whom the history of P. falciparum clinical episodes greatly increased risk of further episodes. Age and a high number of previous falciparum clinical episodes not only play major roles in explaining the risk of P. falciparum episodes but also are risk factors for different groups of people. Combined, they explain the majority of falciparum clinical attacks. Contrary to what is widely believed, clinical immunity to P. falciparum does not de facto occur following many P. falciparum clinical episodes. There exist a sub-group of children who suffer repeated clinical episodes. In addition to posing an important challenge for population stratification during clinical trials, this sub-group disproportionally contributes to the disease burden and may necessitate specific prevention and control measures. © 2013 Loucoubar et al. 2018-10-19T04:31:46Z 2018-10-19T04:31:46Z 2013-02-06 Article PLoS ONE. Vol.8, No.2 (2013) 10.1371/journal.pone.0055666 19326203 2-s2.0-84873549877 https://repository.li.mahidol.ac.th/handle/123456789/31069 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873549877&origin=inward |
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Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology Medicine Cheikh Loucoubar Laura Grange Richard Paul Augustin Huret Adama Tall Olivier Telle Christian Roussilhon Joseph Faye Fatoumata Diene-Sarr Jean François Trape Odile Mercereau-Puijalon Anavaj Sakuntabhai Jean François Bureau High Number of Previous Plasmodium falciparum Clinical Episodes Increases Risk of Future Episodes in a Sub-Group of Individuals |
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There exists great disparity in the number of clinical P. falciparum episodes among children of the same age and living in similar conditions. The epidemiological determinants of such disparity are unclear. We used a data-mining approach to explore a nineteen-year longitudinal malaria cohort study dataset from Senegal and identify variables associated with increased risk of malaria episodes. These were then verified using classical statistics and replicated in a second cohort. In addition to age, we identified a novel high-risk group of children in whom the history of P. falciparum clinical episodes greatly increased risk of further episodes. Age and a high number of previous falciparum clinical episodes not only play major roles in explaining the risk of P. falciparum episodes but also are risk factors for different groups of people. Combined, they explain the majority of falciparum clinical attacks. Contrary to what is widely believed, clinical immunity to P. falciparum does not de facto occur following many P. falciparum clinical episodes. There exist a sub-group of children who suffer repeated clinical episodes. In addition to posing an important challenge for population stratification during clinical trials, this sub-group disproportionally contributes to the disease burden and may necessitate specific prevention and control measures. © 2013 Loucoubar et al. |
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Institut Pasteur, Paris |
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Institut Pasteur, Paris Cheikh Loucoubar Laura Grange Richard Paul Augustin Huret Adama Tall Olivier Telle Christian Roussilhon Joseph Faye Fatoumata Diene-Sarr Jean François Trape Odile Mercereau-Puijalon Anavaj Sakuntabhai Jean François Bureau |
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Article |
author |
Cheikh Loucoubar Laura Grange Richard Paul Augustin Huret Adama Tall Olivier Telle Christian Roussilhon Joseph Faye Fatoumata Diene-Sarr Jean François Trape Odile Mercereau-Puijalon Anavaj Sakuntabhai Jean François Bureau |
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Cheikh Loucoubar |
title |
High Number of Previous Plasmodium falciparum Clinical Episodes Increases Risk of Future Episodes in a Sub-Group of Individuals |
title_short |
High Number of Previous Plasmodium falciparum Clinical Episodes Increases Risk of Future Episodes in a Sub-Group of Individuals |
title_full |
High Number of Previous Plasmodium falciparum Clinical Episodes Increases Risk of Future Episodes in a Sub-Group of Individuals |
title_fullStr |
High Number of Previous Plasmodium falciparum Clinical Episodes Increases Risk of Future Episodes in a Sub-Group of Individuals |
title_full_unstemmed |
High Number of Previous Plasmodium falciparum Clinical Episodes Increases Risk of Future Episodes in a Sub-Group of Individuals |
title_sort |
high number of previous plasmodium falciparum clinical episodes increases risk of future episodes in a sub-group of individuals |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/31069 |
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1763488128563150848 |