Nitric oxide and tumor necrosis factor-alpha inhibitory substances from the rhizomes of Kaempferia marginata
The ethanol extract of the rhizomes of Kaempferia marginata showed a potent inhibitory effect against lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) release in RAW264.7 cells. Moreover, the partition with various organic solvents also inhibited NO producti...
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th-mahidol.311122018-10-19T12:45:51Z Nitric oxide and tumor necrosis factor-alpha inhibitory substances from the rhizomes of Kaempferia marginata Kanidta Kaewkroek Chatchai Wattanapiromsakul Palangpon Kongsaeree Supinya Tewtrakul Prince of Songkla University Mahidol University Agricultural and Biological Sciences Medicine Pharmacology, Toxicology and Pharmaceutics The ethanol extract of the rhizomes of Kaempferia marginata showed a potent inhibitory effect against lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) release in RAW264.7 cells. Moreover, the partition with various organic solvents also inhibited NO production. One new pimarane-type diterpene, 1α- acetoxysandaracopimaradien-2α-ol (5), along with four known diterpenes (1-4), were isolated from the n-hexane and chloroform layers, respectively. Among these metabolites, compounds 1 and 4 were isolated for the first time from K. marginata. Compounds 1-5 showed significant inhibitory effects on NO production, with IC50 values ranging from 38.6 to 51.9 μM. Furthermore, compound 2 also exhibited significant activity against TNF-α release (1C50 = 48.3 μM). These findings may support the use of K. marginata by traditional doctors for treatment of inflammatory-related diseases. 2018-10-19T04:32:48Z 2018-10-19T04:32:48Z 2013-01-01 Article Natural Product Communications. Vol.8, No.9 (2013), 1205-1208 15559475 1934578X 2-s2.0-84886815888 https://repository.li.mahidol.ac.th/handle/123456789/31112 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84886815888&origin=inward |
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Agricultural and Biological Sciences Medicine Pharmacology, Toxicology and Pharmaceutics Kanidta Kaewkroek Chatchai Wattanapiromsakul Palangpon Kongsaeree Supinya Tewtrakul Nitric oxide and tumor necrosis factor-alpha inhibitory substances from the rhizomes of Kaempferia marginata |
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The ethanol extract of the rhizomes of Kaempferia marginata showed a potent inhibitory effect against lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) release in RAW264.7 cells. Moreover, the partition with various organic solvents also inhibited NO production. One new pimarane-type diterpene, 1α- acetoxysandaracopimaradien-2α-ol (5), along with four known diterpenes (1-4), were isolated from the n-hexane and chloroform layers, respectively. Among these metabolites, compounds 1 and 4 were isolated for the first time from K. marginata. Compounds 1-5 showed significant inhibitory effects on NO production, with IC50 values ranging from 38.6 to 51.9 μM. Furthermore, compound 2 also exhibited significant activity against TNF-α release (1C50 = 48.3 μM). These findings may support the use of K. marginata by traditional doctors for treatment of inflammatory-related diseases. |
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Prince of Songkla University |
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Prince of Songkla University Kanidta Kaewkroek Chatchai Wattanapiromsakul Palangpon Kongsaeree Supinya Tewtrakul |
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Article |
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Kanidta Kaewkroek Chatchai Wattanapiromsakul Palangpon Kongsaeree Supinya Tewtrakul |
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Kanidta Kaewkroek |
title |
Nitric oxide and tumor necrosis factor-alpha inhibitory substances from the rhizomes of Kaempferia marginata |
title_short |
Nitric oxide and tumor necrosis factor-alpha inhibitory substances from the rhizomes of Kaempferia marginata |
title_full |
Nitric oxide and tumor necrosis factor-alpha inhibitory substances from the rhizomes of Kaempferia marginata |
title_fullStr |
Nitric oxide and tumor necrosis factor-alpha inhibitory substances from the rhizomes of Kaempferia marginata |
title_full_unstemmed |
Nitric oxide and tumor necrosis factor-alpha inhibitory substances from the rhizomes of Kaempferia marginata |
title_sort |
nitric oxide and tumor necrosis factor-alpha inhibitory substances from the rhizomes of kaempferia marginata |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/31112 |
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1763487411084460032 |