Serotype-specific anti-dengue virus NS1 mouse antibodies cross-react with prM and are potentially involved in virus production

• Main Authors: Promsin Masrinoul, Magot Diata Omokoko, Sabar Pambudi, Kazuyoshi Ikuta, Takeshi Kurosu
• Other Authors: Osaka University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/31253
• Institution: Mahidol University

Dengue virus (DENV) infection induces a strong B-cell immune response against the viral nonstructural protein 1 (NS1). Anti-NS1 antibodies (Abs) may affect virus production because they coexist with the virus in the patients' blood. The present study examined whether ten mouse monoclonal antibo...