Immune activation and viral replication after vaccination with an influenza A H1N1 2009 vaccine in HIV-infected children receiving antiretroviral therapy
Immunization with a pandemic influenza A H1N1 2009 was recommended for HIV-infected patients. However, there is limited information concerning the impact of immunization with this vaccine on immune activation and HIV viral replication. In this study, 45 HIV-infected children and adolescents receivin...
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th-mahidol.314102018-10-19T12:38:38Z Immune activation and viral replication after vaccination with an influenza A H1N1 2009 vaccine in HIV-infected children receiving antiretroviral therapy Nattawat Onlamoon Petai Unpol Michittra Boonchan Kasama Sukapirom Orasri Wittawatmongkol Kulkanya Chokephaibulkit Palanee Ammaranond Kovit Pattanapanyasat Mahidol University Chulalongkorn University Biochemistry, Genetics and Molecular Biology Medicine Immunization with a pandemic influenza A H1N1 2009 was recommended for HIV-infected patients. However, there is limited information concerning the impact of immunization with this vaccine on immune activation and HIV viral replication. In this study, 45 HIV-infected children and adolescents receiving antiretroviral therapy were immunized with a 2-dose series of nonadjuvated monovalent influenza A H1N1 2009 vaccine upon enrollment and approximately 1 month later. Immunogenicity was determined by haemagglutination inhibition assay. The level of immune activation was determined by identification of CD38 and HLA-DR on CD8+ T cells. Patients were divided into 2 groups which include patients who had an undetectable HIV viral load (HIV detectable group) and patients who show virological failure (HIV nondetectable group). The results showed seroconversion rate of 55.2% in HIV nondetectable group, whereas 31.3% was found in HIV detectable group. Both groups of patients showed no major increase in immune activation after immunization. Interestingly, a decrease in the frequency of CD8+ T cells that coexpressed CD38 and HLA-DR was observed after immunization in both groups of patients. We suggested that immunization with influenza A H1N1 2009 vaccine can induce immune response to the pandemic virus without major impact on HIV viral replication and immune activation. © 2013 Nattawat Onlamoon et al. 2018-10-19T04:43:37Z 2018-10-19T04:43:37Z 2013-01-01 Article Disease Markers. Vol.35, No.4 (2013), 221-227 10.1155/2013/276547 18758630 02780240 2-s2.0-84884928540 https://repository.li.mahidol.ac.th/handle/123456789/31410 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884928540&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine Nattawat Onlamoon Petai Unpol Michittra Boonchan Kasama Sukapirom Orasri Wittawatmongkol Kulkanya Chokephaibulkit Palanee Ammaranond Kovit Pattanapanyasat Immune activation and viral replication after vaccination with an influenza A H1N1 2009 vaccine in HIV-infected children receiving antiretroviral therapy |
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Immunization with a pandemic influenza A H1N1 2009 was recommended for HIV-infected patients. However, there is limited information concerning the impact of immunization with this vaccine on immune activation and HIV viral replication. In this study, 45 HIV-infected children and adolescents receiving antiretroviral therapy were immunized with a 2-dose series of nonadjuvated monovalent influenza A H1N1 2009 vaccine upon enrollment and approximately 1 month later. Immunogenicity was determined by haemagglutination inhibition assay. The level of immune activation was determined by identification of CD38 and HLA-DR on CD8+ T cells. Patients were divided into 2 groups which include patients who had an undetectable HIV viral load (HIV detectable group) and patients who show virological failure (HIV nondetectable group). The results showed seroconversion rate of 55.2% in HIV nondetectable group, whereas 31.3% was found in HIV detectable group. Both groups of patients showed no major increase in immune activation after immunization. Interestingly, a decrease in the frequency of CD8+ T cells that coexpressed CD38 and HLA-DR was observed after immunization in both groups of patients. We suggested that immunization with influenza A H1N1 2009 vaccine can induce immune response to the pandemic virus without major impact on HIV viral replication and immune activation. © 2013 Nattawat Onlamoon et al. |
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Mahidol University |
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Mahidol University Nattawat Onlamoon Petai Unpol Michittra Boonchan Kasama Sukapirom Orasri Wittawatmongkol Kulkanya Chokephaibulkit Palanee Ammaranond Kovit Pattanapanyasat |
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Article |
author |
Nattawat Onlamoon Petai Unpol Michittra Boonchan Kasama Sukapirom Orasri Wittawatmongkol Kulkanya Chokephaibulkit Palanee Ammaranond Kovit Pattanapanyasat |
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Nattawat Onlamoon |
title |
Immune activation and viral replication after vaccination with an influenza A H1N1 2009 vaccine in HIV-infected children receiving antiretroviral therapy |
title_short |
Immune activation and viral replication after vaccination with an influenza A H1N1 2009 vaccine in HIV-infected children receiving antiretroviral therapy |
title_full |
Immune activation and viral replication after vaccination with an influenza A H1N1 2009 vaccine in HIV-infected children receiving antiretroviral therapy |
title_fullStr |
Immune activation and viral replication after vaccination with an influenza A H1N1 2009 vaccine in HIV-infected children receiving antiretroviral therapy |
title_full_unstemmed |
Immune activation and viral replication after vaccination with an influenza A H1N1 2009 vaccine in HIV-infected children receiving antiretroviral therapy |
title_sort |
immune activation and viral replication after vaccination with an influenza a h1n1 2009 vaccine in hiv-infected children receiving antiretroviral therapy |
publishDate |
2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/31410 |
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1763489517245825024 |