Miniature short hairpin rna screens to characterize antiproliferative drugs

• Main Authors: Saranya Kittanakom, Anthony Arnoldo, Kevin R. Brown, Iain Wallace, Tada Kunavisarut, Dax Torti, Lawrence E. Heisler, Anuradha Surendra, Jason Moffat, Guri Giaever, Corey Nislow
• Other Authors: Department of Molecular Genetics
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/31425
• Institution: Mahidol University

The application of new proteomics and genomics technologies support a view in which few drugs act solely by inhibiting a single cellular target. Indeed, drug activity is modulated by complex, often incompletely understood cellular mechanisms. Therefore, efforts to decipher mode of action through gen...