The development, physicochemical characterisation and in vitro drug release studies of pectinate gel beads containing thai mango seed kernel extract
Pectinate gel beads containing Thai mango seed kernel extract (MSKE, cultivar 'Fahlun') were developed and characterised for the purpose of colon-targeted delivery. The MSKE-loaded pectinate beads were prepared using ionotropic gelation with varying pectin-to-MSKE ratios, MSKE concentratio...
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th-mahidol.315322018-10-19T12:23:58Z The development, physicochemical characterisation and in vitro drug release studies of pectinate gel beads containing thai mango seed kernel extract Saruth Nithitanakool Pimolpan Pithayanukul Sandrine Bourgeois Hatem Fessi Rapepol Bavovada Mahidol University Laboratoire d'Automatique et de Génie des Procédés Universite Claude Bernard Lyon 1 Chulalongkorn University Chemistry Medicine Pectinate gel beads containing Thai mango seed kernel extract (MSKE, cultivar 'Fahlun') were developed and characterised for the purpose of colon-targeted delivery. The MSKE-loaded pectinate beads were prepared using ionotropic gelation with varying pectin-to-MSKE ratios, MSKE concentrations, and concentrations of two cross-linkers (calcium chloride and zinc acetate). The formulated beads were spherical in shape and ranged in size between 1.13 mm and 1.88 mm. Zinc-pectinate (ZPG) beads containing high amounts of MSKE showed complete entrapment efficiency (EE) of MSKE (100%), while calcium-pectinate (CPG) beads demonstrated 70% EE. The in vitro release tests indicated that MSKE-loaded CPG beads were unstable in both simulated gastric medium (SGM) and simulated intestinal medium (SIM), while MSKE-loaded ZPG beads were stable in SIM but unable to prevent the release of MSKE in SGM. The protection of ZPG beads with gastro-resistant capsules (Eudragit® L 100-55) resulted in stability in both SGM and SIM; they disintegrated immediately in simulated colonic medium containing pectinolytic enzymes. MSKE-loaded ZPG beads were stable at 4, 25 and 45 °C during the study period of four months. The present study revealed that ZPG beads in enteric-coated capsules might be a promising carrier for delivering MSKE to the colon. © 2013 by the authors. 2018-10-19T04:48:11Z 2018-10-19T04:48:11Z 2013-06-01 Article Molecules. Vol.18, No.6 (2013), 6504-6520 10.3390/molecules18066504 14203049 2-s2.0-84879665086 https://repository.li.mahidol.ac.th/handle/123456789/31532 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84879665086&origin=inward |
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Chemistry Medicine Saruth Nithitanakool Pimolpan Pithayanukul Sandrine Bourgeois Hatem Fessi Rapepol Bavovada The development, physicochemical characterisation and in vitro drug release studies of pectinate gel beads containing thai mango seed kernel extract |
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Pectinate gel beads containing Thai mango seed kernel extract (MSKE, cultivar 'Fahlun') were developed and characterised for the purpose of colon-targeted delivery. The MSKE-loaded pectinate beads were prepared using ionotropic gelation with varying pectin-to-MSKE ratios, MSKE concentrations, and concentrations of two cross-linkers (calcium chloride and zinc acetate). The formulated beads were spherical in shape and ranged in size between 1.13 mm and 1.88 mm. Zinc-pectinate (ZPG) beads containing high amounts of MSKE showed complete entrapment efficiency (EE) of MSKE (100%), while calcium-pectinate (CPG) beads demonstrated 70% EE. The in vitro release tests indicated that MSKE-loaded CPG beads were unstable in both simulated gastric medium (SGM) and simulated intestinal medium (SIM), while MSKE-loaded ZPG beads were stable in SIM but unable to prevent the release of MSKE in SGM. The protection of ZPG beads with gastro-resistant capsules (Eudragit® L 100-55) resulted in stability in both SGM and SIM; they disintegrated immediately in simulated colonic medium containing pectinolytic enzymes. MSKE-loaded ZPG beads were stable at 4, 25 and 45 °C during the study period of four months. The present study revealed that ZPG beads in enteric-coated capsules might be a promising carrier for delivering MSKE to the colon. © 2013 by the authors. |
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Mahidol University |
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Mahidol University Saruth Nithitanakool Pimolpan Pithayanukul Sandrine Bourgeois Hatem Fessi Rapepol Bavovada |
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Article |
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Saruth Nithitanakool Pimolpan Pithayanukul Sandrine Bourgeois Hatem Fessi Rapepol Bavovada |
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Saruth Nithitanakool |
title |
The development, physicochemical characterisation and in vitro drug release studies of pectinate gel beads containing thai mango seed kernel extract |
title_short |
The development, physicochemical characterisation and in vitro drug release studies of pectinate gel beads containing thai mango seed kernel extract |
title_full |
The development, physicochemical characterisation and in vitro drug release studies of pectinate gel beads containing thai mango seed kernel extract |
title_fullStr |
The development, physicochemical characterisation and in vitro drug release studies of pectinate gel beads containing thai mango seed kernel extract |
title_full_unstemmed |
The development, physicochemical characterisation and in vitro drug release studies of pectinate gel beads containing thai mango seed kernel extract |
title_sort |
development, physicochemical characterisation and in vitro drug release studies of pectinate gel beads containing thai mango seed kernel extract |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/31532 |
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1763493895316963328 |