Clinical trials of artesunate plus sulfadoxine‑pyrimethamine for Plasmodium falciparum malaria in Afghanistan: maintained efficacy a decade after introduction

• Main Authors: Ghulam Rahim Awab, Mallika Imwong, Sasithon Pukrittayakamee, Fazel Alim, Warunee Hanpithakpong, Joel Tarning, Dondorp, Arjen M., Day, Nicholas P. J., White, Nicholas J., Woodrow, Charles J.
• Other Authors: Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit (MORU)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Open Access article; Malaria; Falciparum; Afghanistan; Artesunate; Sulphadoxine; Pyrimethamine; Dihydrofolate reductase; Dihydropteroate synthase; Piperaquine; Kelch
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/3158
• Institution: Mahidol University

Background: Combination therapy with artesunate plus sulfadoxine-pyrimethamine (SP) was adopted as recommended treatment for Plasmodium falciparum infection in Afghanistan in 2003. Methods: A series of prospective clinical studies examining the efficacy of artesunate plus sulfadoxine-pyrimethamine...