Humanized-VH/VHH that inhibit HCV replication by interfering with the virus helicase activity

• Main Authors: Aninthita Phalaphol, Kanyarat Thueng-in, Jeeraphong Thanongsaksrikul, Ornnuthchar Poungpair, Kunan Bangphoomi, Nitat Sookrung, Potjanee Srimanote, Wanpen Chaicumpa
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/31824

NS3 helicase is a pivotal enzyme involved in the early and late phases of hepatitis C virus (HCV) replication. The primary sequence and tertiary structure of this virus enzyme differ from human helicase to a certain extent; thus this virus protein has potential as a novel anti-HCV target. In this st...