Complement-mediated muscle cell lysis: A possible mechanism of myonecrosis in anti-SRP associated necrotizing myopathy (ASANM)

• Main Authors: Arada Rojana-udomsart, Chalermchai Mitrpant, Christine Bundell, Loren Price, Yue Bei Luo, Victoria Fabian, Steve D. Wilton, Peter Hollingsworth, Frank L. Mastaglia
• Other Authors: University of Western Australia
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine; Neuroscience
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/31869
• Institution: Mahidol University

The mechanism of necrotizing myopathy associated with antibodies to signal recognition particle (SRP) remains unclear. We investigated the effect of anti-SRP. +. serum and complement on cell viability in myoblast cultures. Cell viability was only slightly reduced by incubation with anti-SRP. +. seru...