Triangular test design to evaluate tinidazole in the prevention of Plasmodium vivax relapse

• Main Authors: Louis Macareo, Khin Maung Lwin, Phaik Yeong Cheah, Prayoon Yuentrakul, R. Scott Miller, Francois Nosten
• Other Authors: Walter Reed Army Institute of Research
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/31908
• Institution: Mahidol University

Background: There are very few drugs that prevent the relapse of Plasmodium vivax malaria in man. Tinidazole is a 5-nitroimidazole approved in the USA for the treatment of indications including amoebiasis and giardiasis. In the non-human primate relapsing Plasmodium cynomolgi/macaque malaria model,...