Orientia tsutsugamushi, the causative agent of scrub typhus, induces an inflammatory program in human macrophages

• Main Authors: Wiwit Tantibhedhyangkul, Amira Ben Amara, Julien Textoris, Laurent Gorvel, Eric Ghigo, Christian Capo, Jean Louis Mege
• Other Authors: Unite de Recherche sur les Maladies Infectieuses et Tropicales emergentes
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/31971
• Institution: Mahidol University

Scrub typhus is a life-threatening disease caused by Orientia tsutsugamushi, a bacterium that primarily infects endothelial cells both in vitro and in vivo. Evidence suggests that the interaction of O. tsutsugamushi with myeloid cells may play a pivotal role in O. tsutsugamushi infection. We demonst...