Thalassemia and the hypercoagulable state

Thalassemia, an inherited hemolytic disorder, is associated with a high incidence of thrombosis. The major mechanisms underlying thromboembolism (TE) are an abnormal red blood cell surface, platelet activation and endothelial cell activation. A higher risk of TE is found in splenectomized patients d...

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Main Author:	Nongnuch Sirachainan
Other Authors:	Mahidol University
Format:	Review
Published:	2018
Subjects:	Medicine
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/32049
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Institution:	Mahidol University

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spelling	th-mahidol.320492018-10-19T12:10:49Z Thalassemia and the hypercoagulable state Nongnuch Sirachainan Mahidol University Medicine Thalassemia, an inherited hemolytic disorder, is associated with a high incidence of thrombosis. The major mechanisms underlying thromboembolism (TE) are an abnormal red blood cell surface, platelet activation and endothelial cell activation. A higher risk of TE is found in splenectomized patients due to thrombocytosis and increased abnormal RBCs in the circulation. Regular RBC transfusions can reduce the proportion of abnormal RBCs and suppress erythropoiesis. Regular transfusion may also reduce levels of circulating coagulation markers and reduce elevated pulmonary artery pressure. To prevent thromboembolic events, aspirin is now recommended for splenectomized patients with thrombocytosis. © 2013 Elsevier Ltd. 2018-10-19T05:10:49Z 2018-10-19T05:10:49Z 2013-12-01 Review Thrombosis Research. Vol.132, No.6 (2013), 637-641 10.1016/j.thromres.2013.09.029 18792472 00493848 2-s2.0-84889886728 https://repository.li.mahidol.ac.th/handle/123456789/32049 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84889886728&origin=inward
institution	Mahidol University
building	Mahidol University Library
continent	Asia
country	Thailand Thailand
content_provider	Mahidol University Library
collection	Mahidol University Institutional Repository
topic	Medicine
spellingShingle	Medicine Nongnuch Sirachainan Thalassemia and the hypercoagulable state
description	Thalassemia, an inherited hemolytic disorder, is associated with a high incidence of thrombosis. The major mechanisms underlying thromboembolism (TE) are an abnormal red blood cell surface, platelet activation and endothelial cell activation. A higher risk of TE is found in splenectomized patients due to thrombocytosis and increased abnormal RBCs in the circulation. Regular RBC transfusions can reduce the proportion of abnormal RBCs and suppress erythropoiesis. Regular transfusion may also reduce levels of circulating coagulation markers and reduce elevated pulmonary artery pressure. To prevent thromboembolic events, aspirin is now recommended for splenectomized patients with thrombocytosis. © 2013 Elsevier Ltd.
author2	Mahidol University
author_facet	Mahidol University Nongnuch Sirachainan
format	Review
author	Nongnuch Sirachainan
author_sort	Nongnuch Sirachainan
title	Thalassemia and the hypercoagulable state
title_short	Thalassemia and the hypercoagulable state
title_full	Thalassemia and the hypercoagulable state
title_fullStr	Thalassemia and the hypercoagulable state
title_full_unstemmed	Thalassemia and the hypercoagulable state
title_sort	thalassemia and the hypercoagulable state
publishDate	2018
url	https://repository.li.mahidol.ac.th/handle/123456789/32049
_version_	1763492760368709632

Thalassemia and the hypercoagulable state

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