Overview of lupus nephritis management guidelines and perspective from Asia

Lupus nephritis (LN) is a common and important manifestation of systemic lupus erythematosus (SLE). Evidence suggests higher rates of lupus renal involvement in Asian populations, and maybe more severe nephritis, compared with other racial or ethnic groups. The management of LN has evolved considera...

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Main Authors: Chi Chiu Mok, Desmond Y.H. Yap, Sandra V. Navarra, Zhi Hong Liu, Ming Hui Zhao, Liangjing Lu, Tsutomu Takeuchi, Yingyos Avihingsanon, Xue Qing Yu, Elizabeth A. Lapid, Lenrore R. Lugue-Lizardo, Vasant Sumethkul, Nan Shen, Shun Le Chen, Tak Mao Chan
Other Authors: Tuen Mun Hospital
Format: Review
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/32071
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spelling th-mahidol.320712018-10-19T12:11:39Z Overview of lupus nephritis management guidelines and perspective from Asia Chi Chiu Mok Desmond Y.H. Yap Sandra V. Navarra Zhi Hong Liu Ming Hui Zhao Liangjing Lu Tsutomu Takeuchi Yingyos Avihingsanon Xue Qing Yu Elizabeth A. Lapid Lenrore R. Lugue-Lizardo Vasant Sumethkul Nan Shen Shun Le Chen Tak Mao Chan Tuen Mun Hospital The University of Hong Kong University of Santo Tomas, Manila Jinling Hospital Peking University Renji Hospital Keio University School of Medicine Chulalongkorn University Sun Yat-Sen University Mahidol University Medicine Lupus nephritis (LN) is a common and important manifestation of systemic lupus erythematosus (SLE). Evidence suggests higher rates of lupus renal involvement in Asian populations, and maybe more severe nephritis, compared with other racial or ethnic groups. The management of LN has evolved considerably over the past three decades, based on observations from clinical studies that investigated different immunosuppressive agents including corticosteroids, cyclophosphamide, azathioprine, mycophenolic acid, calcineurin inhibitors and novel biologic therapies. This is accompanied by improvements in both the short-term treatment response rate and long-term renal function preservation. Treatment guidelines for LN have recently been issued by rheumatology and nephrology communities in U.S.A. and Europe. In view of the racial difference in disease manifestation and response to therapy, and the substantial disease burden in Asia, a panel of 15 nephrologists and rheumatologists from different Asian regions with extensive experience in lupus nephritis - the Steering Group for the Asian Lupus Nephritis Network (ALNN) - met and discussed the management of lupus nephritis in Asian patients. The group has also reviewed and deliberated on the recently published recommendations from other parts of the world. This manuscript summarizes the discussions by the group and presents consensus views on the clinical management and treatment of adult Asian patients with LN, taking into account both the available evidence and expert opinion in areas where evidence remains to be sought. © 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd. 2018-10-19T05:11:39Z 2018-10-19T05:11:39Z 2013-12-01 Review International Journal of Rheumatic Diseases. Vol.16, No.6 (2013), 625-636 10.1111/1756-185X.12212 1756185X 17561841 2-s2.0-84891371215 https://repository.li.mahidol.ac.th/handle/123456789/32071 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84891371215&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Chi Chiu Mok
Desmond Y.H. Yap
Sandra V. Navarra
Zhi Hong Liu
Ming Hui Zhao
Liangjing Lu
Tsutomu Takeuchi
Yingyos Avihingsanon
Xue Qing Yu
Elizabeth A. Lapid
Lenrore R. Lugue-Lizardo
Vasant Sumethkul
Nan Shen
Shun Le Chen
Tak Mao Chan
Overview of lupus nephritis management guidelines and perspective from Asia
description Lupus nephritis (LN) is a common and important manifestation of systemic lupus erythematosus (SLE). Evidence suggests higher rates of lupus renal involvement in Asian populations, and maybe more severe nephritis, compared with other racial or ethnic groups. The management of LN has evolved considerably over the past three decades, based on observations from clinical studies that investigated different immunosuppressive agents including corticosteroids, cyclophosphamide, azathioprine, mycophenolic acid, calcineurin inhibitors and novel biologic therapies. This is accompanied by improvements in both the short-term treatment response rate and long-term renal function preservation. Treatment guidelines for LN have recently been issued by rheumatology and nephrology communities in U.S.A. and Europe. In view of the racial difference in disease manifestation and response to therapy, and the substantial disease burden in Asia, a panel of 15 nephrologists and rheumatologists from different Asian regions with extensive experience in lupus nephritis - the Steering Group for the Asian Lupus Nephritis Network (ALNN) - met and discussed the management of lupus nephritis in Asian patients. The group has also reviewed and deliberated on the recently published recommendations from other parts of the world. This manuscript summarizes the discussions by the group and presents consensus views on the clinical management and treatment of adult Asian patients with LN, taking into account both the available evidence and expert opinion in areas where evidence remains to be sought. © 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.
author2 Tuen Mun Hospital
author_facet Tuen Mun Hospital
Chi Chiu Mok
Desmond Y.H. Yap
Sandra V. Navarra
Zhi Hong Liu
Ming Hui Zhao
Liangjing Lu
Tsutomu Takeuchi
Yingyos Avihingsanon
Xue Qing Yu
Elizabeth A. Lapid
Lenrore R. Lugue-Lizardo
Vasant Sumethkul
Nan Shen
Shun Le Chen
Tak Mao Chan
format Review
author Chi Chiu Mok
Desmond Y.H. Yap
Sandra V. Navarra
Zhi Hong Liu
Ming Hui Zhao
Liangjing Lu
Tsutomu Takeuchi
Yingyos Avihingsanon
Xue Qing Yu
Elizabeth A. Lapid
Lenrore R. Lugue-Lizardo
Vasant Sumethkul
Nan Shen
Shun Le Chen
Tak Mao Chan
author_sort Chi Chiu Mok
title Overview of lupus nephritis management guidelines and perspective from Asia
title_short Overview of lupus nephritis management guidelines and perspective from Asia
title_full Overview of lupus nephritis management guidelines and perspective from Asia
title_fullStr Overview of lupus nephritis management guidelines and perspective from Asia
title_full_unstemmed Overview of lupus nephritis management guidelines and perspective from Asia
title_sort overview of lupus nephritis management guidelines and perspective from asia
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/32071
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