Exercise capacity and ventilatory response during exercise in COPD patients with and without β blockade

Background: Although β blockade (BB) in patients with chronic obstructive pulmonary disease (COPD) does not show signs of worsening pulmonary function or respiratory symptoms, the effects on cardiopulmonary exercise testing (CPET) remain unclear. The aim of this study was to determine whether BB aff...

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Main Authors: Wilawan Thirapatarapong, Hilary F. Armstrong, Matthew N. Bartels
Other Authors: Mahidol University
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Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/32144
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spelling th-mahidol.321442018-10-19T12:15:33Z Exercise capacity and ventilatory response during exercise in COPD patients with and without β blockade Wilawan Thirapatarapong Hilary F. Armstrong Matthew N. Bartels Mahidol University Columbia University Medical Center Medicine Background: Although β blockade (BB) in patients with chronic obstructive pulmonary disease (COPD) does not show signs of worsening pulmonary function or respiratory symptoms, the effects on cardiopulmonary exercise testing (CPET) remain unclear. The aim of this study was to determine whether BB affects exercise capacity, gas exchange, and hemodynamic responses in patients with COPD. Methods: Twenty-four COPD subjects on BB were matched to 24 COPD subjects without BB according to age, gender, body mass index, and severity of COPD. All subjects underwent resting pulmonary function and symptom-limited CPET. Results: Comparing COPD patients with and without BB revealed that percent peak oxygen consumption and VE/VCO2 nadir were not significantly different (45 ± 16 vs. 51 ± 23 %, p = 0.30, and 35.1 ± 8.5 vs. 36.2 ± 11.6 %, p = 0.69). Systolic blood pressure and heart rate at peak exercise were significantly decreased in COPD patients with BB (168 ± 16 vs. 185 ± 20 mmHg, and 109 ± 16 vs. 122 ± 14 bpm, respectively, p < 0.05). Conclusion: Exercise capacity and gas exchange remain unaffected in patients with COPD in the presence of BB, although heart rate and blood pressure are lower. These findings imply that BB does not adversely affect functional capacity in patients with COPD. © 2013 Springer Science+Business Media New York. 2018-10-19T05:15:33Z 2018-10-19T05:15:33Z 2013-10-01 Article Lung. Vol.191, No.5 (2013), 531-536 10.1007/s00408-013-9492-2 14321750 03412040 2-s2.0-84884819629 https://repository.li.mahidol.ac.th/handle/123456789/32144 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884819629&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Wilawan Thirapatarapong
Hilary F. Armstrong
Matthew N. Bartels
Exercise capacity and ventilatory response during exercise in COPD patients with and without β blockade
description Background: Although β blockade (BB) in patients with chronic obstructive pulmonary disease (COPD) does not show signs of worsening pulmonary function or respiratory symptoms, the effects on cardiopulmonary exercise testing (CPET) remain unclear. The aim of this study was to determine whether BB affects exercise capacity, gas exchange, and hemodynamic responses in patients with COPD. Methods: Twenty-four COPD subjects on BB were matched to 24 COPD subjects without BB according to age, gender, body mass index, and severity of COPD. All subjects underwent resting pulmonary function and symptom-limited CPET. Results: Comparing COPD patients with and without BB revealed that percent peak oxygen consumption and VE/VCO2 nadir were not significantly different (45 ± 16 vs. 51 ± 23 %, p = 0.30, and 35.1 ± 8.5 vs. 36.2 ± 11.6 %, p = 0.69). Systolic blood pressure and heart rate at peak exercise were significantly decreased in COPD patients with BB (168 ± 16 vs. 185 ± 20 mmHg, and 109 ± 16 vs. 122 ± 14 bpm, respectively, p < 0.05). Conclusion: Exercise capacity and gas exchange remain unaffected in patients with COPD in the presence of BB, although heart rate and blood pressure are lower. These findings imply that BB does not adversely affect functional capacity in patients with COPD. © 2013 Springer Science+Business Media New York.
author2 Mahidol University
author_facet Mahidol University
Wilawan Thirapatarapong
Hilary F. Armstrong
Matthew N. Bartels
format Article
author Wilawan Thirapatarapong
Hilary F. Armstrong
Matthew N. Bartels
author_sort Wilawan Thirapatarapong
title Exercise capacity and ventilatory response during exercise in COPD patients with and without β blockade
title_short Exercise capacity and ventilatory response during exercise in COPD patients with and without β blockade
title_full Exercise capacity and ventilatory response during exercise in COPD patients with and without β blockade
title_fullStr Exercise capacity and ventilatory response during exercise in COPD patients with and without β blockade
title_full_unstemmed Exercise capacity and ventilatory response during exercise in COPD patients with and without β blockade
title_sort exercise capacity and ventilatory response during exercise in copd patients with and without β blockade
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/32144
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