Switching HIV Treatment in Adults Based on CD4 Count Versus Viral Load Monitoring: A Randomized, Non-Inferiority Trial in Thailand

• Main Authors: Gonzague Jourdain, Sophie Le Cœur, Nicole Ngo-Giang-Huong, Patrinee Traisathit, Tim R. Cressey, Federica Fregonese, Baptiste Leurent, Intira J. Collins, Malee Techapornroong, Sukit Banchongkit, Sudanee Buranabanjasatean, Guttiga Halue, Ampaipith Nilmanat, Nuananong Luekamlung, Virat Klinbuayaem, Apichat Chutanunta, Pacharee Kantipong, Chureeratana Bowonwatanuwong, Rittha Lertkoonalak, Prattana Leenasirimakul, Somboon Tansuphasawasdikul, Pensiriwan Sang-a-gad, Panita Pathipvanich, Srisuda Thongbuaban, Pakorn Wittayapraparat, Naree Eiamsirikit, Yuwadee Buranawanitchakorn, Naruepon Yutthakasemsunt, Narong Winiyakul, Luc Decker, Sylvaine Barbier, Suporn Koetsawang, Wasna Sirirungsi, Kenneth McIntosh, Sombat Thanprasertsuk, Marc Lallemant, A. Lautissier, S. Renaudin, E. Delacour, N. Chaiboonruang, T. Sriwised, T. Tritungtrakul, D. Punyatiam, P. Pirom, S. Jitharidkul, P. Palidta, S. Vorayutthanakarn, N. Rawanchaikul, S. Nupradit, T. Tankool, W. Champa, J. Krasaesuk, G. Ganjina, K. Thanin-at, R. Wongsang, M. Inta, N. Mungkhala, P. Saenchitta, K. Oopin, P. Wimolwattanasarn, S. Chalermpantmetagul, R. Peongjakta, C. Kanabkaew, J. Chaiwan, M. Y. Meynard, P. Sukrakanchana, B. Ratchanee, J. Thonglo, J. Khanmali, N. Kruenual, N. Krapunpongsakul, P. Krueduangkam, R. Kaewsai, R. Wongchai, S. Jinasa, T. Thimakam, W. Pongchaisit, W. Khamjakkaew, S. Thammajitsagul, J. Wallapachai, J. Chalasin, P. Kulchatchai, N. Thuenyeanyong, P. Thuraset, P. Pinklow, P. Chart
• Other Authors: Institute of research for development, Thailand
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/32246
• Institution: Mahidol University

Background:Viral load (VL) is recommended for monitoring the response to highly active antiretroviral therapy (HAART) but is not routinely available in most low- and middle-income countries. The purpose of the study was to determine whether a CD4-based monitoring and switching strategy would provide...