Baseline CD4 cell counts and outcomes among adult treatment naïve HIV patients after taking fixed dose combination GPO-VIR-S and GPO-VIR-Z in Thailand

A retrospective study was conducted by reviewing 459 medical records of adult treatment naïve HIV patients who received a fixed dose combination of GPO-VIR-S (stavudine, lamivudine and nevirapine) or GPO-VIR-Z (zidovudine, lamivudine and nevirapine) at Ramathibodi Hospital in Bangkok, Thailand durin...

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Main Authors: Nyan Lin Kyaw, Vipa Thanachartwet, Sasisopin Kiertiburanakul, Varunee Desakorn, Supat Chamnanchanunt, Wirongrong Chierakul, Weerawat Manosuthi, Punnee Pitisuttithum, Somnuek Sungkanuparph
Other Authors: Mahidol University
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Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/32341
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spelling th-mahidol.323412018-10-19T12:24:42Z Baseline CD4 cell counts and outcomes among adult treatment naïve HIV patients after taking fixed dose combination GPO-VIR-S and GPO-VIR-Z in Thailand Nyan Lin Kyaw Vipa Thanachartwet Sasisopin Kiertiburanakul Varunee Desakorn Supat Chamnanchanunt Wirongrong Chierakul Weerawat Manosuthi Punnee Pitisuttithum Somnuek Sungkanuparph Mahidol University Bamrasnaradura Infectious Diseases Institute Medicine A retrospective study was conducted by reviewing 459 medical records of adult treatment naïve HIV patients who received a fixed dose combination of GPO-VIR-S (stavudine, lamivudine and nevirapine) or GPO-VIR-Z (zidovudine, lamivudine and nevirapine) at Ramathibodi Hospital in Bangkok, Thailand during 2002-2009 following Thai National Treatment Guideline for adults with HIV. The aim of this study was to assess the association between the baseline CD4 cell count and outcome. The median CD4 cell count at baseline, 6, 12 and 102 months were 102 cells/μl, 213 cells/μl, 274 cells/μl and 423 cells/μl. The virologic response (p=0.327), virologic rebound (p=0.626), adverse effects of anti-retroviral therapy (ART) (p=0.976), switching to other ART (p=0.245), occurrence of immune reconstitution inflammatory syndrome (IRIS) (p>0.05) and occurrence of drug resistance (p=0.952) were not significantly associated with baseline CD4 count. The Kaplan-Meier estimate showed the median time (95% CI) to achieve virologic response was 10.4 (9.8-11.0) months and the median time to achieve virologic rebound was 30.0 (21.6-38.4) months after initiation of ART. Analysis showed the median time to achieved virologic response (p=0.401) and virologic rebound (p=0.562) were not significantly associated with the baseline CD4 count. This study shows the outcome after onset of ART did not vary by baseline CD4 cell count. 2018-10-19T05:24:42Z 2018-10-19T05:24:42Z 2013-05-22 Article Southeast Asian Journal of Tropical Medicine and Public Health. Vol.44, No.2 (2013), 232 01251562 2-s2.0-84877857666 https://repository.li.mahidol.ac.th/handle/123456789/32341 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84877857666&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Nyan Lin Kyaw
Vipa Thanachartwet
Sasisopin Kiertiburanakul
Varunee Desakorn
Supat Chamnanchanunt
Wirongrong Chierakul
Weerawat Manosuthi
Punnee Pitisuttithum
Somnuek Sungkanuparph
Baseline CD4 cell counts and outcomes among adult treatment naïve HIV patients after taking fixed dose combination GPO-VIR-S and GPO-VIR-Z in Thailand
description A retrospective study was conducted by reviewing 459 medical records of adult treatment naïve HIV patients who received a fixed dose combination of GPO-VIR-S (stavudine, lamivudine and nevirapine) or GPO-VIR-Z (zidovudine, lamivudine and nevirapine) at Ramathibodi Hospital in Bangkok, Thailand during 2002-2009 following Thai National Treatment Guideline for adults with HIV. The aim of this study was to assess the association between the baseline CD4 cell count and outcome. The median CD4 cell count at baseline, 6, 12 and 102 months were 102 cells/μl, 213 cells/μl, 274 cells/μl and 423 cells/μl. The virologic response (p=0.327), virologic rebound (p=0.626), adverse effects of anti-retroviral therapy (ART) (p=0.976), switching to other ART (p=0.245), occurrence of immune reconstitution inflammatory syndrome (IRIS) (p>0.05) and occurrence of drug resistance (p=0.952) were not significantly associated with baseline CD4 count. The Kaplan-Meier estimate showed the median time (95% CI) to achieve virologic response was 10.4 (9.8-11.0) months and the median time to achieve virologic rebound was 30.0 (21.6-38.4) months after initiation of ART. Analysis showed the median time to achieved virologic response (p=0.401) and virologic rebound (p=0.562) were not significantly associated with the baseline CD4 count. This study shows the outcome after onset of ART did not vary by baseline CD4 cell count.
author2 Mahidol University
author_facet Mahidol University
Nyan Lin Kyaw
Vipa Thanachartwet
Sasisopin Kiertiburanakul
Varunee Desakorn
Supat Chamnanchanunt
Wirongrong Chierakul
Weerawat Manosuthi
Punnee Pitisuttithum
Somnuek Sungkanuparph
format Article
author Nyan Lin Kyaw
Vipa Thanachartwet
Sasisopin Kiertiburanakul
Varunee Desakorn
Supat Chamnanchanunt
Wirongrong Chierakul
Weerawat Manosuthi
Punnee Pitisuttithum
Somnuek Sungkanuparph
author_sort Nyan Lin Kyaw
title Baseline CD4 cell counts and outcomes among adult treatment naïve HIV patients after taking fixed dose combination GPO-VIR-S and GPO-VIR-Z in Thailand
title_short Baseline CD4 cell counts and outcomes among adult treatment naïve HIV patients after taking fixed dose combination GPO-VIR-S and GPO-VIR-Z in Thailand
title_full Baseline CD4 cell counts and outcomes among adult treatment naïve HIV patients after taking fixed dose combination GPO-VIR-S and GPO-VIR-Z in Thailand
title_fullStr Baseline CD4 cell counts and outcomes among adult treatment naïve HIV patients after taking fixed dose combination GPO-VIR-S and GPO-VIR-Z in Thailand
title_full_unstemmed Baseline CD4 cell counts and outcomes among adult treatment naïve HIV patients after taking fixed dose combination GPO-VIR-S and GPO-VIR-Z in Thailand
title_sort baseline cd4 cell counts and outcomes among adult treatment naïve hiv patients after taking fixed dose combination gpo-vir-s and gpo-vir-z in thailand
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/32341
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