Rivastigmine patch for treatment of Alzheimer's disease in clinical practice in Thailand
Background: Rivastigmine is a cholinesterase inhibitor for treatment of mild to moderate Alzheimer's disease (AD) and dementia associated with Parkinson's disease. The new patch formulation was recently made available. We assessed the safety, tolerability, and cognitive outcome of rivastig...
Saved in:
Main Authors: | , , , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Published: |
2018
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/32475 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
id |
th-mahidol.32475 |
---|---|
record_format |
dspace |
spelling |
th-mahidol.324752018-10-19T12:42:05Z Rivastigmine patch for treatment of Alzheimer's disease in clinical practice in Thailand Kongkiat Kulkantrakorn Panas Tanyakitpisal Somchai Towanabut Charungthai Dejthevaporn Poonsri Rangseekajee Sunsanee Pongpakdee Somsak Laptikultham Kritsada Rodprasert Suwanna Setthawatcharawanich Bandit Thinkhamrop Faculty of Medicine, Thammasat University Bhumibhol Adulyadej Hospital Somdet Chaopraya Hosp. Prasat Neurological Institute Mahidol University Rajavithi Hospital Khon Kaen University Prince of Songkla University Ratchaburi Regional Hospital Medicine Nursing Background: Rivastigmine is a cholinesterase inhibitor for treatment of mild to moderate Alzheimer's disease (AD) and dementia associated with Parkinson's disease. The new patch formulation was recently made available. We assessed the safety, tolerability, and cognitive outcome of rivastigmine patch in treatment of mild to moderate AD in clinical practice in Thailand. Methods: A multicentre, hospital-based, prospective observational study was conducted in nine hospitals across Thailand. Patients with probable mild to moderate AD who received the rivastigmine patch were enrolled. Data were collected data at baseline, weeks 4-8 and after week16. Results: A total of 116 AD patients were screened, and three were excluded. Of 113 patients, 62.8% were women with a mean age of 73.3±9.2years; 79.7% were newly diagnosed. One-third of all patients had been using antipsychotic or antidepressant medication. Common comorbidities were hypertension and dyslipidemia. The Thai Mental State Examination score significantly increased from 18.6 to 20.3 (weeks 4-8) and 20.4 (week 16+) (P<0.001). Scores based on physicians' (Clinical Global Impression) and caregivers' (Patients' Caregiver Global Impression of Change) impressions of improvement suggested minimal improvement. Because of adverse events, seven patients's dosages were reduced 10cm2 to 5cm2 or from 5cm2 to nothing. Itching was the most common adverse symptom. Conclusions: During the first 16weeks after initiation of rivastigmine patch therapy, patients with probable mild to moderate AD had statistically significant improvement in cognitive function, but clinically marginal benefit. Rivastigmine was safe and well tolerated. © 2012 The Authors. Psychogeriatrics © 2012 Japanese Psychogeriatric Society. 2018-10-19T05:31:01Z 2018-10-19T05:31:01Z 2013-03-01 Article Psychogeriatrics. Vol.13, No.1 (2013), 1-8 10.1111/j.1479-8301.2012.00403.x 14798301 13463500 2-s2.0-84875682239 https://repository.li.mahidol.ac.th/handle/123456789/32475 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84875682239&origin=inward |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
topic |
Medicine Nursing |
spellingShingle |
Medicine Nursing Kongkiat Kulkantrakorn Panas Tanyakitpisal Somchai Towanabut Charungthai Dejthevaporn Poonsri Rangseekajee Sunsanee Pongpakdee Somsak Laptikultham Kritsada Rodprasert Suwanna Setthawatcharawanich Bandit Thinkhamrop Rivastigmine patch for treatment of Alzheimer's disease in clinical practice in Thailand |
description |
Background: Rivastigmine is a cholinesterase inhibitor for treatment of mild to moderate Alzheimer's disease (AD) and dementia associated with Parkinson's disease. The new patch formulation was recently made available. We assessed the safety, tolerability, and cognitive outcome of rivastigmine patch in treatment of mild to moderate AD in clinical practice in Thailand. Methods: A multicentre, hospital-based, prospective observational study was conducted in nine hospitals across Thailand. Patients with probable mild to moderate AD who received the rivastigmine patch were enrolled. Data were collected data at baseline, weeks 4-8 and after week16. Results: A total of 116 AD patients were screened, and three were excluded. Of 113 patients, 62.8% were women with a mean age of 73.3±9.2years; 79.7% were newly diagnosed. One-third of all patients had been using antipsychotic or antidepressant medication. Common comorbidities were hypertension and dyslipidemia. The Thai Mental State Examination score significantly increased from 18.6 to 20.3 (weeks 4-8) and 20.4 (week 16+) (P<0.001). Scores based on physicians' (Clinical Global Impression) and caregivers' (Patients' Caregiver Global Impression of Change) impressions of improvement suggested minimal improvement. Because of adverse events, seven patients's dosages were reduced 10cm2 to 5cm2 or from 5cm2 to nothing. Itching was the most common adverse symptom. Conclusions: During the first 16weeks after initiation of rivastigmine patch therapy, patients with probable mild to moderate AD had statistically significant improvement in cognitive function, but clinically marginal benefit. Rivastigmine was safe and well tolerated. © 2012 The Authors. Psychogeriatrics © 2012 Japanese Psychogeriatric Society. |
author2 |
Faculty of Medicine, Thammasat University |
author_facet |
Faculty of Medicine, Thammasat University Kongkiat Kulkantrakorn Panas Tanyakitpisal Somchai Towanabut Charungthai Dejthevaporn Poonsri Rangseekajee Sunsanee Pongpakdee Somsak Laptikultham Kritsada Rodprasert Suwanna Setthawatcharawanich Bandit Thinkhamrop |
format |
Article |
author |
Kongkiat Kulkantrakorn Panas Tanyakitpisal Somchai Towanabut Charungthai Dejthevaporn Poonsri Rangseekajee Sunsanee Pongpakdee Somsak Laptikultham Kritsada Rodprasert Suwanna Setthawatcharawanich Bandit Thinkhamrop |
author_sort |
Kongkiat Kulkantrakorn |
title |
Rivastigmine patch for treatment of Alzheimer's disease in clinical practice in Thailand |
title_short |
Rivastigmine patch for treatment of Alzheimer's disease in clinical practice in Thailand |
title_full |
Rivastigmine patch for treatment of Alzheimer's disease in clinical practice in Thailand |
title_fullStr |
Rivastigmine patch for treatment of Alzheimer's disease in clinical practice in Thailand |
title_full_unstemmed |
Rivastigmine patch for treatment of Alzheimer's disease in clinical practice in Thailand |
title_sort |
rivastigmine patch for treatment of alzheimer's disease in clinical practice in thailand |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/32475 |
_version_ |
1763492724383678464 |