Functional diffusion-weighted magnetic resonance spectroscopy of the human primary visual cortex at 7 T
Purpose: Microstructural and metabolic changes directly related to neuronal activation have been investigated using functional diffusion-weighted spectroscopy. Methods: The volume of interest was positioned in the primary visual cortex. A time series of alternating diffusion- and non-diffusion- weig...
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| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/32528 |
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| Institution: | Mahidol University |
| Summary: | Purpose: Microstructural and metabolic changes directly related to neuronal activation have been investigated using functional diffusion-weighted spectroscopy. Methods: The volume of interest was positioned in the primary visual cortex. A time series of alternating diffusion- and non-diffusion- weighted1H spectra was acquired at 7 T employing stimulated echo acquisition mode sequence and a long diffusion time (Δ = 245 ms). Time-resolved series of metabolite apparent diffusion coefficient values were derived. Results: Significant increases in apparent diffusion coefficient of 3.3 ± 1.4% (p = 0.05) and 3.9 ± 0.9% (p = 0.002) for total n-acetyl aspartate and total creatine, respectively, and 8.1 ± 2.5% (p = 0.03) for total choline were observed in response to visual stimulation. Conclusion: The increase in apparent diffusion coefficient for these metabolites is a potential indication for microstructural changes in neurons during neural activation and/or for an increase in the energy-dependent cytoplasmic streaming associated with enhanced metabolism during visual stimulation. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc. Copyright © 2012 Wiley Periodicals, Inc. |
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