Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy
Mycobacterium tuberculosis infection is one of many opportunistic infections in renal transplant recipients, arising either from reactivation of latent infection or de novo infection, occasionally donor derived. M. tuberculosis hepatitis has never been reported in patients who have received alemtuzu...
Saved in:
Main Authors: | , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Published: |
2018
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/32548 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
id |
th-mahidol.32548 |
---|---|
record_format |
dspace |
spelling |
th-mahidol.325482018-10-19T12:33:28Z Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy W. Bosch N. Poowanawittayakom K. Chaikriangkrai J. Mendez W. C. Hellinger T. A. Gonwa M. Krishna S. Pungpapong Mayo Clinic in Jacksonville, Florida Mahidol University Medicine Mycobacterium tuberculosis infection is one of many opportunistic infections in renal transplant recipients, arising either from reactivation of latent infection or de novo infection, occasionally donor derived. M. tuberculosis hepatitis has never been reported in patients who have received alemtuzumab as part of their renal transplant management. We describe 2 patients who underwent deceased-donor renal transplantation following alemtuzumab induction therapy and presented with a febrile syndrome, subsequently diagnosed as tuberculous hepatitis, one with disseminated disease. Both responded well to treatment without significant side effects, resulting in excellent graft function. The importance of chemoprophylaxis should be emphasized to minimize the risk of developing active tuberculosis in patients with latent tuberculosis infection undergoing solid organ transplantation. © 2012 John Wiley & Sons A/S. 2018-10-19T05:33:28Z 2018-10-19T05:33:28Z 2013-02-01 Article Transplant Infectious Disease. Vol.15, No.1 (2013) 10.1111/tid.12048 13993062 13982273 2-s2.0-84873415399 https://repository.li.mahidol.ac.th/handle/123456789/32548 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873415399&origin=inward |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
topic |
Medicine |
spellingShingle |
Medicine W. Bosch N. Poowanawittayakom K. Chaikriangkrai J. Mendez W. C. Hellinger T. A. Gonwa M. Krishna S. Pungpapong Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy |
description |
Mycobacterium tuberculosis infection is one of many opportunistic infections in renal transplant recipients, arising either from reactivation of latent infection or de novo infection, occasionally donor derived. M. tuberculosis hepatitis has never been reported in patients who have received alemtuzumab as part of their renal transplant management. We describe 2 patients who underwent deceased-donor renal transplantation following alemtuzumab induction therapy and presented with a febrile syndrome, subsequently diagnosed as tuberculous hepatitis, one with disseminated disease. Both responded well to treatment without significant side effects, resulting in excellent graft function. The importance of chemoprophylaxis should be emphasized to minimize the risk of developing active tuberculosis in patients with latent tuberculosis infection undergoing solid organ transplantation. © 2012 John Wiley & Sons A/S. |
author2 |
Mayo Clinic in Jacksonville, Florida |
author_facet |
Mayo Clinic in Jacksonville, Florida W. Bosch N. Poowanawittayakom K. Chaikriangkrai J. Mendez W. C. Hellinger T. A. Gonwa M. Krishna S. Pungpapong |
format |
Article |
author |
W. Bosch N. Poowanawittayakom K. Chaikriangkrai J. Mendez W. C. Hellinger T. A. Gonwa M. Krishna S. Pungpapong |
author_sort |
W. Bosch |
title |
Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy |
title_short |
Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy |
title_full |
Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy |
title_fullStr |
Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy |
title_full_unstemmed |
Tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy |
title_sort |
tuberculous hepatitis in renal transplant recipients following alemtuzumab induction therapy |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/32548 |
_version_ |
1763496356838637568 |