Population pharmacokinetic and pharmacodynamic properties of intramuscular quinine in tanzanian children with severe falciparum malaria

• Main Authors: Ilse C E Hendriksen, Deogratius Maig, Martha M. Lemnge, George Mtove, Samwel Gesas, Hugh Reyburn, Niklas Lindegardh, Nicholas P J Day, Lorenz Von Seidlein, Arjen M. Dondorp, Joel Tarning, Nicholas J. White
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/32560

Although artesunate is clearly superior, parenteral quinine is still used widely for the treatment of severe malaria.A loading-dose regimen has been recommended for 30 years but is still often not used.A population pharmacokinetic study was conducted with 75 Tanzanian children aged 4 months to 8 yea...