Gastric acid inhibition of Capsicum extract in isolated mouse whole stomach

• Main Authors: Utaipat A, Chareonsuk S, Thongyen A, Thirawarapan SS, Suvitayavat W
• Other Authors: Mahidol University. Faculty of Pharmacy. Department of Pharmacology
• Format: Original Article
• Language: English
• Published: 2017
• Subjects: Isolated mouse whole stomach; Gastric acid secretion; Capsicum extract; สารสกัดพริก; การหลั่งกรดของกระเพาะอาหาร; Thai Journal of Phytopharmacy; วารสารสมุนไพร; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/3263
• Institution: Mahidol University

The purpose of this study was to determine the effect of capsicum extract on gastric acid secretion induced by histamine and bethanechol using the isolated mouse stomach model. Gastric acid secretions were collected every 10 minutes. After collecting the first sample, capsicum extract was applied to the serosal solution in the organ bath. 20 minutes after applying capsicum extract, 5 μM histamine or 100 μM bethanechol was applied. This study has found that capsicum extract could reduce gastric acid secretion induced by histamine. Capsicum extract at concentrations of 8 and 16 μg/ ml significantly reduced gastric acid secretion, 8 μg/ml producing the greatest effect on reduction of cumulative acid secretion. The inhibitory effect of capsicum extract (8 μg/ml) on acid secretion induced by histamine was reduced in the presence of indomethacin (0.1 μM), suggesting a role of prostaglandins in the capsicum response. In contrast to histamine-induced secretion, 8 μg/ml capsicum extract did not decrease gastric acid secretion induced by bethanechol. In summary, capsicum extract at a concentration of 8 μg/ml reduced gastric acid secretion induced by histamine, partially reduced this secretion through prostaglandins but had no effect on induction of gastric secretion by bethanechol.