8-Hydroxyquinolines: A review of their metal chelating properties and medicinal applications

Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a...

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Main Authors: Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
Other Authors: Mahidol University
Format: Review
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/32729
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spelling th-mahidol.327292018-10-19T12:42:50Z 8-Hydroxyquinolines: A review of their metal chelating properties and medicinal applications Veda Prachayasittikul Supaluk Prachayasittikul Somsak Ruchirawat Virapong Prachayasittikul Mahidol University Chulabhorn Research Institute Pharmacology, Toxicology and Pharmaceutics Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure-activity relationships. © 2013 Prachayasittikul et al. 2018-10-19T05:42:50Z 2018-10-19T05:42:50Z 2013-10-03 Review Drug Design, Development and Therapy. Vol.7, (2013), 1157-1178 10.2147/DDDT.S49763 11778881 2-s2.0-84885060514 https://repository.li.mahidol.ac.th/handle/123456789/32729 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84885060514&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
Veda Prachayasittikul
Supaluk Prachayasittikul
Somsak Ruchirawat
Virapong Prachayasittikul
8-Hydroxyquinolines: A review of their metal chelating properties and medicinal applications
description Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure-activity relationships. © 2013 Prachayasittikul et al.
author2 Mahidol University
author_facet Mahidol University
Veda Prachayasittikul
Supaluk Prachayasittikul
Somsak Ruchirawat
Virapong Prachayasittikul
format Review
author Veda Prachayasittikul
Supaluk Prachayasittikul
Somsak Ruchirawat
Virapong Prachayasittikul
author_sort Veda Prachayasittikul
title 8-Hydroxyquinolines: A review of their metal chelating properties and medicinal applications
title_short 8-Hydroxyquinolines: A review of their metal chelating properties and medicinal applications
title_full 8-Hydroxyquinolines: A review of their metal chelating properties and medicinal applications
title_fullStr 8-Hydroxyquinolines: A review of their metal chelating properties and medicinal applications
title_full_unstemmed 8-Hydroxyquinolines: A review of their metal chelating properties and medicinal applications
title_sort 8-hydroxyquinolines: a review of their metal chelating properties and medicinal applications
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/32729
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