An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome-wide association studies

• Main Authors: Damrongrit Setsirichok, Phuwadej Tienboon, Nattapong Jaroonruang, Somkit Kittichaijaroen, Waranyu Wongseree, Theera Piroonratana, Touchpong Usavanarong, Chanin Limwongse, Chatchawit Aporntewan, Marongx Phadoongsidhi, Nachol Chaiyaratana
• Other Authors: King Mongkut's University of Technology North Bangkok
• Format: Article
• Published: 2018
• Subjects: Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/32823
• Institution: Mahidol University

This article presents the ability of an omnibus permutation test on ensembles of two-locus analyses (2LOmb) to detect pure epistasis in the presence of genetic heterogeneity. The performance of 2LOmb is evaluated in various simulation scenarios covering two independent causes of complex disease wher...