Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element

• Main Authors: Apilak Wutthisathapornchai, Tuangtong Vongpipatana, Sureeporn Muangsawat, Thirajit Boonsaen, Michael J. MacDonald, Sarawut Jitrapakdee
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33003

Pyruvate carboxylase (PC) is an anaplerotic enzyme that regulates glucose-induced insulin secretion in pancreatic islets. Dysregulation of its expression is associated with type 2 diabetes. Herein we describe the molecular mechanism underlying the glucose-mediated transcriptional regulation of the P...