Antisense oligonucleotide induction of progerin in human myogenic cells

Antisense oligonucleotide induction of progerin in human myogenic cells

We sought to use splice-switching antisense oligonucleotides to produce a model of accelerated ageing by enhancing expression of progerin, translated from a mis-spliced lamin A gene ( LMNA) transcript in human myogenic cells. The progerin transcript (LMNA Δ150) lacks the last 150 bases of exon 11, a...

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Bibliographic Details
Main Authors: Yue Bei Luo, Chalermchai Mitrpant, Abbie M. Adams, Russell D. Johnsen, Sue Fletcher, Frank L. Mastaglia, Steve D. Wilton
Other Authors: University of Western Australia
Format: Article
Published: 2018
Subjects:
Agricultural and Biological Sciences
Biochemistry, Genetics and Molecular Biology
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/33012
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/33012

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