Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries

• Main Authors: Naowarat Tanomsing, Mayfong Mayxay, Paul N. Newton, Francois Nosten, Christiane Dolecek, Tran Tinh Hien, Nicholas J. White, Nicholas P.J. Day, Arjen M. Dondorp, Mallika Imwong
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33028

The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfa...