Origin of robustness in generating drug-resistant malaria parasites

• Main Authors: Krittikorn Kümpornsin, Charin Modchang, Adina Heinberg, Eric H. Ekland, Piyaporn Jirawatcharadech, Pornpimol Chobson, Nattida Suwanakitti, Sastra Chaotheing, Prapon Wilairat, Kirk W. Deitsch, Sumalee Kamchonwongpaisan, David A. Fidock, Laura A. Kirkman, Yongyuth Yuthavong, Thanat Chookajorn
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33161

Biological robustness allows mutations to accumulate while maintaining functional phenotypes. Despite its crucial role in evolutionary processes, the mechanistic details of how robustness originates remain elusive. Using an evolutionary trajectory analysis approach, we demonstrate how robustness evo...