Comparison of Methods to Account for Relatedness in Genome-Wide Association Studies with Family-Based Data

• Main Authors: Jakris Eu-ahsunthornwattana, E. Nancy Miller, Michaela Fakiola, Selma M.B. Jeronimo, Jenefer M. Blackwell, Heather J. Cordell
• Other Authors: Newcastle University, United Kingdom
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33170
• Institution: Mahidol University

Approaches based on linear mixed models (LMMs) have recently gained popularity for modelling population substructure and relatedness in genome-wide association studies. In the last few years, a bewildering variety of different LMM methods/software packages have been developed, but it is not always c...