Molecular diagnosis of α-thalassemias by the colorimetric nanogold

• Main Authors: Sirinart Chomean, Nantawan Wangmaung, Pornpimol Sritongkham, Chamras Promptmas, Sumana Mas-oodi, Dalina Tanyong, Wanida Ittarat
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Environmental Science
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33314

A new application of gold nanoparticles (AuNPs) as a colorimetric method for gene detection of α-thalassemia 1 (SEA deletion) is reported here for the first time. This technique is based on color changes from salt-induced aggregation of un-hybridized nanogold probes after hybridization with the targ...