Caspase-1-Dependent and -Independent Cell Death Pathways in Burkholderia pseudomallei Infection of Macrophages

• Main Authors: Antje Bast, Kathrin Krause, Imke H.E. Schmidt, Matsayapan Pudla, Stefanie Brakopp, Verena Hopf, Katrin Breitbach, Ivo Steinmetz
• 其他作者: Friedrich-Loeffler-Institute
• 格式: Article
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/33368

The cytosolic pathogen Burkholderia pseudomallei and causative agent of melioidosis has been shown to regulate IL-1β and IL-18 production through NOD-like receptor NLRP3 and pyroptosis via NLRC4. Downstream signalling pathways of those receptors and other cell death mechanisms induced during B. pseu...