Adiponectin mediated APPL1-AMPK signaling induces cell migration, MMP activation, and collagen remodeling in cardiac fibroblasts

• Main Authors: Keith Dadson, Helen Chasiotis, Sivaporn Wannaiampikul, Rungsunn Tungtrongchitr, Aimin Xu, Gary Sweeney
• Other Authors: York University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33399
• Institution: Mahidol University

Defects in adiponectin action have been implicated in the development of cardiac dysfunction in obesity and diabetes. Cardiac fibroblasts play an important role in regulating extracellular matrix remodeling yet little is known regarding the direct effects of adiponectin on cardiac fibroblasts. In th...