In Vivo Administration of a JAK3 Inhibitor during Acute SIV Infection Leads to Significant Increases in Viral Load during Chronic Infection

• Main Authors: Yoshiaki Takahashi, Siddappa N. Byrareddy, Christina Albrecht, Markus Brameier, Lutz Walter, Ann E. Mayne, Paul Dunbar, Robert Russo, Dawn M. Little, Tara Villinger, Ladawan Khowawisetsut, Kovit Pattanapanyasat, Francois Villinger, Aftab A. Ansari
• Other Authors: Emory University School of Medicine
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33414
• Institution: Mahidol University

The studies reported herein are the first to document the effect of the in vivo administration of a JAK3 inhibitor for defining the potential role of NK cells during acute SIV infection of a group of 15 rhesus macaques (RM). An additional group of 16 MHC/KIR typed RM was included as controls. The pr...