Sequence and apoptotic activity of VacA cytotoxin cloned from a helicobacter pylori thai clinical isolate

• Main Authors: Muhammad Junaid, Sarbast Al-Gubare, Muhammad Yousef, Mathukorn Na Ubol, Somphob Leetachewa, Chatchai Muanprasat, Chanan Angsuthanasombat, Wanpen Chaicumpa, Niaz Ali, Gerd Katzenmeier
• Other Authors: University of Malakand
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33440
• Institution: Mahidol University

The vacuolating cytotoxin VacA produced by Helicobacter pylori induces the formation of large cytoplasmic vacuoles in host gastric epithelial cells as well as a release of cytochrome C from mitochondria resulting in cell apoptosis. Considerable sequence diversity in VacA relating to different degree...