Synthesis and anticervical cancer activity of novel pH responsive micelles for oral curcumin delivery

• Main Authors: Warayuth Sajomsang, Pattarapond Gonil, Somsak Saesoo, Uracha Rangsadthong Ruktanonchai, Wanwisa Srinuanchai, Satit Puttipipatkhachorn
• Other Authors: Thailand National Science and Technology Development Agency
• Format: Article
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/34150
• Institution: Mahidol University

© 2014 Elsevier B.V. All rights reserved. Curcumin (CM) has demonstrated safety and efficacy as a drug, but its pharmaceutical role is restricted as a result of extremely low aqueous solubility, rapid systemic elimination, inadequate tissue absorption and degradation at alkaline pH; properties that...