Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder
Background: To treat patients suffering from treatment-resistant major depressive disorder (TR-MDD), research has focused on electroconvulsive therapy (ECT) and aerobic exercise training (AET). Brain derived neurotrophic factor (BDNF) seems to be key in MDD. The aims of the present study were theref...
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th-mahidol.348062018-11-09T10:08:13Z Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder Iraj Salehi Seyed Mohammad Hosseini Mohammad Haghighi Leila Jahangard Hafez Bajoghli Markus Gerber Uwe Pühse Roumen Kirov Edith Holsboer-Trachsler Serge Brand Hamedan University of Medical Sciences Tehran University of Medical Sciences Mahidol University Universitat Basel Bulgarian Academy of Sciences Universitaren Psychiatrischen Kliniken Basel Medicine Neuroscience Background: To treat patients suffering from treatment-resistant major depressive disorder (TR-MDD), research has focused on electroconvulsive therapy (ECT) and aerobic exercise training (AET). Brain derived neurotrophic factor (BDNF) seems to be key in MDD. The aims of the present study were therefore two-fold, to investigate in a three-arm interventional study the differential effects of ECT, ECT plus AET, and AET alone in patients suffering from TR-MDD on 1. depressive symptoms and 2. BDNF. Methods: 60 patients with TR-MDD (mean age: 31 years; 31.6% female patients) were randomly assigned either to the ECT, ECT + AET, or AET condition. The AET condition consisted of treadmill exercise for 30 min, three times a week. Both depression severity and BDNF levels were assessed at baseline and 4 weeks later. All patients were further treated with an SSRI standard medication. Results: BDNF levels increased over time in all three study conditions. After completion of the intervention program, the ECT group showed significantly higher BDNF levels compared to the ECT + AET and the AET conditions. Depressive symptoms decreased in all three conditions over time. The combination of ECT + AET led to a significantly greater decrease than in either the ECT or AET alone conditions. BDNF levels were not associated with symptoms of depression. Conclusions: The pattern of results suggests that ECT, AET and particularly their combination are promising directions for treatment patients suffering from TR-MDD, and that it remains unclear to what extent BDNF is key and a reliable biomarker for TR-MDD. © 2014 Elsevier Ltd. 2018-11-09T03:03:15Z 2018-11-09T03:03:15Z 2014-01-01 Article Journal of Psychiatric Research. Vol.57, No.1 (2014), 117-124 10.1016/j.jpsychires.2014.06.018 18791379 00223956 2-s2.0-84905567865 https://repository.li.mahidol.ac.th/handle/123456789/34806 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84905567865&origin=inward |
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Medicine Neuroscience Iraj Salehi Seyed Mohammad Hosseini Mohammad Haghighi Leila Jahangard Hafez Bajoghli Markus Gerber Uwe Pühse Roumen Kirov Edith Holsboer-Trachsler Serge Brand Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder |
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Background: To treat patients suffering from treatment-resistant major depressive disorder (TR-MDD), research has focused on electroconvulsive therapy (ECT) and aerobic exercise training (AET). Brain derived neurotrophic factor (BDNF) seems to be key in MDD. The aims of the present study were therefore two-fold, to investigate in a three-arm interventional study the differential effects of ECT, ECT plus AET, and AET alone in patients suffering from TR-MDD on 1. depressive symptoms and 2. BDNF. Methods: 60 patients with TR-MDD (mean age: 31 years; 31.6% female patients) were randomly assigned either to the ECT, ECT + AET, or AET condition. The AET condition consisted of treadmill exercise for 30 min, three times a week. Both depression severity and BDNF levels were assessed at baseline and 4 weeks later. All patients were further treated with an SSRI standard medication. Results: BDNF levels increased over time in all three study conditions. After completion of the intervention program, the ECT group showed significantly higher BDNF levels compared to the ECT + AET and the AET conditions. Depressive symptoms decreased in all three conditions over time. The combination of ECT + AET led to a significantly greater decrease than in either the ECT or AET alone conditions. BDNF levels were not associated with symptoms of depression. Conclusions: The pattern of results suggests that ECT, AET and particularly their combination are promising directions for treatment patients suffering from TR-MDD, and that it remains unclear to what extent BDNF is key and a reliable biomarker for TR-MDD. © 2014 Elsevier Ltd. |
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Hamedan University of Medical Sciences |
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Hamedan University of Medical Sciences Iraj Salehi Seyed Mohammad Hosseini Mohammad Haghighi Leila Jahangard Hafez Bajoghli Markus Gerber Uwe Pühse Roumen Kirov Edith Holsboer-Trachsler Serge Brand |
format |
Article |
author |
Iraj Salehi Seyed Mohammad Hosseini Mohammad Haghighi Leila Jahangard Hafez Bajoghli Markus Gerber Uwe Pühse Roumen Kirov Edith Holsboer-Trachsler Serge Brand |
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Iraj Salehi |
title |
Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder |
title_short |
Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder |
title_full |
Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder |
title_fullStr |
Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder |
title_full_unstemmed |
Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder |
title_sort |
electroconvulsive therapy and aerobic exercise training increased bdnf and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/34806 |
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1763488579419373568 |