Selective TGF-β1/ALK inhibitor improves neuronal differentiation of mouse embryonic stem cells

• Main Authors: Nuttha Klincumhom, Theerawat Tharasanit, Chommanart Thongkittidilok, Narong Tiptanavattana, Sasitorn Rungarunlert, András Dinnyés, Mongkol Techakumphu
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2018
• Subjects: Neuroscience
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/34887
• Institution: Mahidol University

The transforming growth factor-β1 (TGF-β1), a polypeptide member of the TGF-β superfamily, has myriad cellular functions, including cell fate differentiation. We hypothesized that suppression of TGF-β1 signaling would improve the efficacy of neuronal differentiation during embryoid body (EB) develop...