Encapsulation of poorly water-soluble drugs into organic nanotubes for improving drug dissolution

• Main Authors: Kunikazu Moribe, Takashi Makishima, Kenjirou Higashi, Nan Liu, Waree Limwikrant, Wuxiao Ding, Mitsutoshi Masuda, Toshimi Shimizu, Keiji Yamamoto
• Other Authors: Chiba University
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/34900
• Institution: Mahidol University

Hydrocortisone (HC), a poorly water-soluble drug, was encapsulated within organic nanotubes (ONTs), which were formed via the self-assembly of N-{12-[(2-α,β-d-glucopyranosyl) carbamoyl]dodecanyl}- glycylglycylglycine acid. The stability of the ONTs was evaluated in ten organic solvents, of differing...