Rational design of a series of novel amphipathic cell-penetrating peptides

• Main Authors: Jakob Regberg, Artita Srimanee, Mikael Erlandsson, Rannar Sillard, Dimitar A. Dobchev, Mati Karelson, Ülo Langel
• Other Authors: Stockholms universitet
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/34904
• Institution: Mahidol University

A series of novel, amphipathic cell-penetrating peptides was developed based on a combination of the model amphipathic peptide sequence and modifications based on the strategies developed for PepFect and NickFect peptides. The aim was to study the role of amphipathicity for peptide uptake and to inv...