Induction of apoptosis in cholangiocarcinoma by an andrographolide analogue is mediated through topoisomerase II alpha inhibition

• Main Authors: Jintapat Nateewattana, Suman Dutta, Somrudee Reabroi, Rungnapha Saeeng, Sakkasem Kasemsook, Arthit Chairoungdua, Jittima Weerachayaphorn, Sopit Wongkham, Pawinee Piyachaturawat
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/34908

Cholangiocarcinoma (CCA), the common primary malignant tumor of bile duct epithelial cells, is unresponsive to most chemotherapeutic drugs. Diagnosis with CCA has a poor prognosis, and therefore urgently requires effective therapeutic agents. In the present study we investigated anti-cancer effects...