Curcumin i mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells

• Main Authors: Benjawan Meesarapee, Anusorn Thampithak, Yamaratee Jaisin, Pimtip Sanvarinda, Apichart Suksamrarn, Patoomratana Tuchinda, Noppawan Phumala Morales, Yupin Sanvarinda
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/34919

6-Hydroxydopamine (6-OHDA) selectively enters dopaminergic neurons and undergoes auto-oxidation resulting in the generation of reactive oxygen species and dopamine quinones, subsequently leading to apoptosis. This mechanism mimics the pathogenesis of Parkinson's disease and has been used to ind...