Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death
© The Author 2015. Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular deat...
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th-mahidol.354502018-11-23T16:42:32Z Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death Kannan Badri Narayanan Manaf Ali Barry J. Barclay Qiang Cheng Leandro D'Abronzo Rita Dornetshuber-Fleiss Paramita M. Ghosh Michael J. Gonzalez Guzman Tae Jin Lee Po Sing Leung Lin Li Suidjit Luanpitpong Edward Ratovitski Yon Rojanasakul Maria Fiammetta Romano Simona Romano Ranjeet Kumar Sinha Clement Yedjou Fahd Al-Mulla Rabeah Al-Temaimi Amedeo Amedei Dustin G. Brown Elizabeth P. Ryan Annamaria Colacci Roslida A. Hamid Chiara Mondello Jayadev Raju Hosni K. Salem Jordan Woodrick Ivana Scovassi Neetu Singh Monica Vaccari Rabindra Roy Stefano Forte Lorenzo Memeo Seo Yun Kim William H. Bisson Leroy Lowe Hyun Ho Park Yeungnam University Universiti Sultan Zainal Abidin Plant Biotechnologies Inc Southern Illinois University University of California, Davis Universitat Wien University of Puerto Rico Chinese University of Hong Kong Mahidol University The Johns Hopkins School of Medicine West Virginia University Robert C. Byrd Health Sciences Center Universita degli Studi di Napoli Federico II Scripps Research Institute Jackson State University University of Kuwait Universita degli Studi di Firenze Colorado State University Environmental Protection and Health Prevention Agency Universiti Putra Malaysia Consiglio Nazionale delle Ricerche Toxicology Research Division Cairo University Lombardi Comprehensive Cancer Center Chhatrapati Shahuji Maharaj Medical University Mediterranean Institute of Oncology Korea Cancer Center Hospital Oregon State University Getting to Know Cancer Biochemistry, Genetics and Molecular Biology © The Author 2015. Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of prosurvival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of proapoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis. 2018-11-23T09:42:32Z 2018-11-23T09:42:32Z 2015-06-01 Review Carcinogenesis. Vol.36, (2015), S89-S110 10.1093/carcin/bgv032 14602180 01433334 2-s2.0-84937698903 https://repository.li.mahidol.ac.th/handle/123456789/35450 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84937698903&origin=inward |
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Biochemistry, Genetics and Molecular Biology Kannan Badri Narayanan Manaf Ali Barry J. Barclay Qiang Cheng Leandro D'Abronzo Rita Dornetshuber-Fleiss Paramita M. Ghosh Michael J. Gonzalez Guzman Tae Jin Lee Po Sing Leung Lin Li Suidjit Luanpitpong Edward Ratovitski Yon Rojanasakul Maria Fiammetta Romano Simona Romano Ranjeet Kumar Sinha Clement Yedjou Fahd Al-Mulla Rabeah Al-Temaimi Amedeo Amedei Dustin G. Brown Elizabeth P. Ryan Annamaria Colacci Roslida A. Hamid Chiara Mondello Jayadev Raju Hosni K. Salem Jordan Woodrick Ivana Scovassi Neetu Singh Monica Vaccari Rabindra Roy Stefano Forte Lorenzo Memeo Seo Yun Kim William H. Bisson Leroy Lowe Hyun Ho Park Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
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© The Author 2015. Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of prosurvival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of proapoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis. |
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Yeungnam University |
author_facet |
Yeungnam University Kannan Badri Narayanan Manaf Ali Barry J. Barclay Qiang Cheng Leandro D'Abronzo Rita Dornetshuber-Fleiss Paramita M. Ghosh Michael J. Gonzalez Guzman Tae Jin Lee Po Sing Leung Lin Li Suidjit Luanpitpong Edward Ratovitski Yon Rojanasakul Maria Fiammetta Romano Simona Romano Ranjeet Kumar Sinha Clement Yedjou Fahd Al-Mulla Rabeah Al-Temaimi Amedeo Amedei Dustin G. Brown Elizabeth P. Ryan Annamaria Colacci Roslida A. Hamid Chiara Mondello Jayadev Raju Hosni K. Salem Jordan Woodrick Ivana Scovassi Neetu Singh Monica Vaccari Rabindra Roy Stefano Forte Lorenzo Memeo Seo Yun Kim William H. Bisson Leroy Lowe Hyun Ho Park |
format |
Review |
author |
Kannan Badri Narayanan Manaf Ali Barry J. Barclay Qiang Cheng Leandro D'Abronzo Rita Dornetshuber-Fleiss Paramita M. Ghosh Michael J. Gonzalez Guzman Tae Jin Lee Po Sing Leung Lin Li Suidjit Luanpitpong Edward Ratovitski Yon Rojanasakul Maria Fiammetta Romano Simona Romano Ranjeet Kumar Sinha Clement Yedjou Fahd Al-Mulla Rabeah Al-Temaimi Amedeo Amedei Dustin G. Brown Elizabeth P. Ryan Annamaria Colacci Roslida A. Hamid Chiara Mondello Jayadev Raju Hosni K. Salem Jordan Woodrick Ivana Scovassi Neetu Singh Monica Vaccari Rabindra Roy Stefano Forte Lorenzo Memeo Seo Yun Kim William H. Bisson Leroy Lowe Hyun Ho Park |
author_sort |
Kannan Badri Narayanan |
title |
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
title_short |
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
title_full |
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
title_fullStr |
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
title_full_unstemmed |
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
title_sort |
disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/35450 |
_version_ |
1763489301276917760 |