A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

• Main Authors: Friederike I. Nollmann, Antje K. Heinrich, Alexander O. Brachmann, Christophe Morisseau, Krishnendu Mukherjee, Ángel M. Casanova-Torres, Frederic Strobl, David Kleinhans, Sebastian Kinski, Katharina Schultz, Michael L. Beeton, Marcel Kaiser, Ya Yun Chu, Long Phan Ke, Aunchalee Thanwisai, Kenan A.J. Bozhüyük, Narisara Chantratita, Friedrich Götz, Nick R. Waterfield, Andreas Vilcinskas, Ernst H.K. Stelzer, Heidi Goodrich-Blair, Bruce D. Hammock, Helge B. Bode
• Other Authors: Goethe-Universitat Frankfurt am Main
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/35485
• Institution: Mahidol University

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.