Urinary bisphenol A detection is significantly associated with young and obese Thai children

Background: Bisphenol A (BPA), a xenoestrogenic monomer, is one of the most common industrial chemicals used in epoxy coatings for canned food and other consumer items. There is only limited information regarding the potential health risks from BPA exposure in children and adolescents from Asian cou...

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Main Authors: Sopon Pornkunwilai, Wichit Nosoongnoen, Chutima Jantarat, Suttipong Wachrasindhu, Vichit Supornsilchai
Other Authors: King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/35583
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spelling th-mahidol.355832018-11-23T16:49:10Z Urinary bisphenol A detection is significantly associated with young and obese Thai children Sopon Pornkunwilai Wichit Nosoongnoen Chutima Jantarat Suttipong Wachrasindhu Vichit Supornsilchai King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University Mahidol University Walailak University Biochemistry, Genetics and Molecular Biology Background: Bisphenol A (BPA), a xenoestrogenic monomer, is one of the most common industrial chemicals used in epoxy coatings for canned food and other consumer items. There is only limited information regarding the potential health risks from BPA exposure in children and adolescents from Asian countries. Objective: To detect and determine urinary BPA concentrations, and identify possible association between urinary BPA levels, demographic characteristics, and BPA exposure risks in Thai children and adolescents. Methods: A cross-sectional study was conducted in 376 children and adolescents aged 3-18 years from kindergarten, elementary, and middle schools in Bangkok, Thailand. Urinary concentrations of total BPA were determined by liquid chromatography tandem mass spectrometry (LC-MSMS). Anthropometric data and questionnaires regarding BPA exposure risks were collected. Results: BPA was detected in 283 of 376 urine samples (75.3%) with a median adjusted BPA 0.53 μg/g creatinine (range 0.04-1.12). Thirty-one participants (9%) were overweight and 39 (11%) were obese. The BPA detection rate was significantly higher in obese children (OR 3.42, 95% confidence interval (CI) 1.18-9.95, P = 0.02) compared with children of normal weight. BPA was detected more often in younger children (3-6 years) when compared with children (6-10 years) and adolescents (10-18 years). There were no significant association between BPA levels and other demographic data or BPA exposure risks. Conclusions: BPA exposure in Thai children and adolescents may be lower than exposure in children from the United States, some European nations, and other Asian countries. Obese and younger children were significantly associated with BPA detection. 2018-11-23T09:49:10Z 2018-11-23T09:49:10Z 2015-01-01 Article Asian Biomedicine. Vol.9, No.3 (2015), 363-372 10.5372/1905-7415.0903.405 1875855X 19057415 2-s2.0-84939451126 https://repository.li.mahidol.ac.th/handle/123456789/35583 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84939451126&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Sopon Pornkunwilai
Wichit Nosoongnoen
Chutima Jantarat
Suttipong Wachrasindhu
Vichit Supornsilchai
Urinary bisphenol A detection is significantly associated with young and obese Thai children
description Background: Bisphenol A (BPA), a xenoestrogenic monomer, is one of the most common industrial chemicals used in epoxy coatings for canned food and other consumer items. There is only limited information regarding the potential health risks from BPA exposure in children and adolescents from Asian countries. Objective: To detect and determine urinary BPA concentrations, and identify possible association between urinary BPA levels, demographic characteristics, and BPA exposure risks in Thai children and adolescents. Methods: A cross-sectional study was conducted in 376 children and adolescents aged 3-18 years from kindergarten, elementary, and middle schools in Bangkok, Thailand. Urinary concentrations of total BPA were determined by liquid chromatography tandem mass spectrometry (LC-MSMS). Anthropometric data and questionnaires regarding BPA exposure risks were collected. Results: BPA was detected in 283 of 376 urine samples (75.3%) with a median adjusted BPA 0.53 μg/g creatinine (range 0.04-1.12). Thirty-one participants (9%) were overweight and 39 (11%) were obese. The BPA detection rate was significantly higher in obese children (OR 3.42, 95% confidence interval (CI) 1.18-9.95, P = 0.02) compared with children of normal weight. BPA was detected more often in younger children (3-6 years) when compared with children (6-10 years) and adolescents (10-18 years). There were no significant association between BPA levels and other demographic data or BPA exposure risks. Conclusions: BPA exposure in Thai children and adolescents may be lower than exposure in children from the United States, some European nations, and other Asian countries. Obese and younger children were significantly associated with BPA detection.
author2 King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University
author_facet King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University
Sopon Pornkunwilai
Wichit Nosoongnoen
Chutima Jantarat
Suttipong Wachrasindhu
Vichit Supornsilchai
format Article
author Sopon Pornkunwilai
Wichit Nosoongnoen
Chutima Jantarat
Suttipong Wachrasindhu
Vichit Supornsilchai
author_sort Sopon Pornkunwilai
title Urinary bisphenol A detection is significantly associated with young and obese Thai children
title_short Urinary bisphenol A detection is significantly associated with young and obese Thai children
title_full Urinary bisphenol A detection is significantly associated with young and obese Thai children
title_fullStr Urinary bisphenol A detection is significantly associated with young and obese Thai children
title_full_unstemmed Urinary bisphenol A detection is significantly associated with young and obese Thai children
title_sort urinary bisphenol a detection is significantly associated with young and obese thai children
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/35583
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